Reaction Details Report a problem with these data
Target
Glycine receptor subunit alpha-1
Ligand
BDBM50415206
Substrate
n/a
Meas. Tech.
ChEMBL_606507 (CHEMBL1065458)
IC50
79.43±n/a nM
Citation
 Maksay, G; Vincze, Z; Nemes, P Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors. Bioorg Med Chem 17:6872-8 (2009) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-1
Synonyms:
GLRA1_RAT | Glra1 | Glycine receptor alpha-1 chain | Glycine receptor subunit alpha-1 | Glycine, non-strychnine | Glycine, strychnine | Glyr
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52629.37
Organism:
RAT
Description:
Glycine, non-strychnine 0 RAT::P07727
Residue:
457
Sequence:
MYSFNTLRFYLWETIVFFSLAASKEADAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPAPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK
  
Inhibitor
Name:
BDBM50415206
Synonyms:
CHEMBL596257
Type:
Small organic molecule
Emp. Form.:
C12H15NO3
Mol. Mass.:
221.2524
SMILES:
O=C(OC1C[C@H]2CC[C@H](C1)N2)c1ccco1 |r,TLB:2:3:10:6.7|
Structure:
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