Reaction Details Report a problem with these data
Target
Glycine receptor subunit alpha-1
Ligand
BDBM50304335
Substrate
n/a
Meas. Tech.
ChEMBL_606513 (CHEMBL1065464)
IC50
1.07±n/a nM
Citation
 Maksay, G; Vincze, Z; Nemes, P Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors. Bioorg Med Chem 17:6872-8 (2009) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-1
Synonyms:
GLRA1_RAT | Glra1 | Glycine receptor alpha-1 chain | Glycine receptor subunit alpha-1 | Glycine, non-strychnine | Glycine, strychnine | Glyr
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52629.37
Organism:
RAT
Description:
Glycine, non-strychnine 0 RAT::P07727
Residue:
457
Sequence:
MYSFNTLRFYLWETIVFFSLAASKEADAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQDDEGGEGRFNFSAYGMGPACLQAKDGISVKGANNNNTTNPAPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK
  
Inhibitor
Name:
BDBM50304335
Synonyms:
3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-nortropane | CHEMBL608710
Type:
Small organic molecule
Emp. Form.:
C17H20N2O2
Mol. Mass.:
284.3529
SMILES:
Cn1c(cc2ccccc12)C(=O)OC1C[C@H]2CC[C@H](C1)N2 |r,TLB:12:13:20:16.17|
Structure:
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