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Target
Tyrosine-protein kinase CSK
Ligand
BDBM50305146
Substrate
n/a
Meas. Tech.
ChEMBL_603268 (CHEMBL1049492)
IC50
4.5±n/a nM
Citation
 Takayama, T; Umemiya, H; Amada, H; Yabuuchi, T; Shiozawa, F; Katakai, H; Takaoka, A; Yamaguchi, A; Endo, M; Sato, M Pyrrole derivatives as potent inhibitors of lymphocyte-specific kinase: Structure, synthesis, and SAR. Bioorg Med Chem Lett 20:108-11 (2010) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase CSK
Synonyms:
C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK
Type:
Tyrosine-protein kinase
Mol. Mass.:
50707.30
Organism:
Homo sapiens (Human)
Description:
P41240
Residue:
450
Sequence:
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
  
Inhibitor
Name:
BDBM50305146
Synonyms:
4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl)-1H-pyrrole-3-carboxamide | CHEMBL589630
Type:
Small organic molecule
Emp. Form.:
C24H17F2N3O3
Mol. Mass.:
433.4069
SMILES:
NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F
Structure:
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