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Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM50305330
Substrate
n/a
Meas. Tech.
ChEMBL_603517 (CHEMBL1068436)
IC50
10±n/a nM
Citation
 Harada, K; Kubo, H; Tomigahara, Y; Nishioka, K; Takahashi, J; Momose, M; Inoue, S; Kojima, A Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer. Bioorg Med Chem Lett 20:272-5 (2010) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2
Type:
Enzyme
Mol. Mass.:
34525.39
Organism:
Homo sapiens (Human)
Description:
P37058
Residue:
310
Sequence:
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR
  
Inhibitor
Name:
BDBM50305330
Synonyms:
7-hydroxy-4-((thiazol-2-ylthio)methyl)-2H-chromen-2-one | CHEMBL589156
Type:
Small organic molecule
Emp. Form.:
C13H9NO3S2
Mol. Mass.:
291.345
SMILES:
Oc1ccc2c(CSc3nccs3)cc(=O)oc2c1
Structure:
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