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Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM50305336
Substrate
n/a
Meas. Tech.
ChEMBL_603517 (CHEMBL1068436)
IC50
8±n/a nM
Citation
 Harada, K; Kubo, H; Tomigahara, Y; Nishioka, K; Takahashi, J; Momose, M; Inoue, S; Kojima, A Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer. Bioorg Med Chem Lett 20:272-5 (2010) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2
Type:
Enzyme
Mol. Mass.:
34525.39
Organism:
Homo sapiens (Human)
Description:
P37058
Residue:
310
Sequence:
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR
  
Inhibitor
Name:
BDBM50305336
Synonyms:
7-hydroxy-4-(2-(6-methylpyridin-2-yl)ethyl)-2H-chromen-2-one | CHEMBL589396
Type:
Small organic molecule
Emp. Form.:
C17H15NO3
Mol. Mass.:
281.3059
SMILES:
Cc1cccc(CCc2cc(=O)oc3cc(O)ccc23)n1
Structure:
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