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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50307082
Substrate
n/a
Meas. Tech.
ChEMBL_609358 (CHEMBL1072744)
IC50
5±n/a nM
Citation
 Long, JZ; Jin, X; Adibekian, A; Li, W; Cravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem 53:1830-42 (2010) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH1_MOUSE | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Hydrolase; single-pass membrane protein; homodimer
Mol. Mass.:
63227.28
Organism:
Mus musculus (mouse)
Description:
Mouse brain membranes were used in the assay.
Residue:
579
Sequence:
MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQRFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCEDLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTLVPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMKKGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
  
Inhibitor
Name:
BDBM50307082
Synonyms:
4-Nitrophenyl 4-(3-(3-(Trifluoromethyl)phenoxy)benzyl)piperazine-1-carboxylate | CHEMBL601002
Type:
Small organic molecule
Emp. Form.:
C25H22F3N3O5
Mol. Mass.:
501.4545
SMILES:
[O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3cccc(Oc4cccc(c4)C(F)(F)F)c3)CC2)cc1
Structure:
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