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Target
Secreted frizzled-related protein 1
Ligand
BDBM50308695
Substrate
n/a
Meas. Tech.
ChEMBL_607293 (CHEMBL1072835)
EC50
420±n/a nM
Citation
 Moore, WJ; Kern, JC; Bhat, R; Bodine, PV; Fukyama, S; Krishnamurthy, G; Magolda, RL; Pitts, K; Stauffer, B; Trybulski, EJ Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg Med Chem 18:190-201 (2010) [PubMed]  Article 
Target
Name:
Secreted frizzled-related protein 1
Synonyms:
FRP | FRP1 | SARP2 | SFRP1 | SFRP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
35404.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1363191
Residue:
314
Sequence:
MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
  
Inhibitor
Name:
BDBM50308695
Synonyms:
CHEMBL590304 | tert-Butyl 4-{[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C29H36F3N3O7S2
Mol. Mass.:
659.737
SMILES:
CC(C)(C)OC(=O)N1CCC(CC1)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Structure:
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