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Target
B1 bradykinin receptor
Ligand
BDBM50308997
Substrate
n/a
Meas. Tech.
ChEMBL_612385 (CHEMBL1066271)
IC50
1±n/a nM
Citation
 Schaudt, M; Locardi, E; Zischinsky, G; Stragies, R; Pfeifer, JR; Gibson, C; Scharn, D; Richter, U; Kalkhof, H; Dinkel, K; Schnatbaum, K Novel small molecule bradykinin B1 receptor antagonists. Part 1: benzamides and semicarbazides. Bioorg Med Chem Lett 20:1225-8 (2010) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50308997
Synonyms:
CHEMBL591742 | N-((R)-1-(5-((2R,5S)-2,5-dimethylpyrrolidine-1-carbonyl)-3-fluoropyridin-2-yl)ethyl)-1-ethyl-2-(3-fluoro-5-(trifluoromethyl)benzoyl)hydrazinecarboxamide
Type:
Small organic molecule
Emp. Form.:
C25H28F5N5O3
Mol. Mass.:
541.5135
SMILES:
CCN(NC(=O)c1cc(F)cc(c1)C(F)(F)F)C(=O)N[C@H](C)c1ncc(cc1F)C(=O)N1[C@@H](C)CC[C@H]1C |r|
Structure:
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