Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50309021
Substrate
n/a
Meas. Tech.
ChEMBL_612393 (CHEMBL1066279)
IC50
0.7±n/a nM
Citation
Zischinsky, G; Stragies, R; Schaudt, M; Pfeifer, JR; Gibson, C; Locardi, E; Scharn, D; Richter, U; Kalkhof, H; Dinkel, K; Schnatbaum, K Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles. Bioorg Med Chem Lett 20:1229-32 (2010) [PubMed] Article
More Info.:
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Inhibitor
Name:
BDBM50309021
Synonyms:
CHEMBL591676 | N-(2-((5'-chloro-3,3'-difluoro-2'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methylamino)-1H-benzo[d]imidazol-1-yl)-3-methoxyisoxazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C28H20ClF2N7O4
Mol. Mass.:
591.953
SMILES:
COc1cc(on1)C(=O)Nn1c(NCc2ccc(cc2F)-c2cc(Cl)cc(F)c2-c2noc(C)n2)nc2ccccc12