Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50309025
Substrate
n/a
Meas. Tech.
ChEMBL_612393 (CHEMBL1066279)
IC50
1±n/a nM
Citation
 Zischinsky, G; Stragies, R; Schaudt, M; Pfeifer, JR; Gibson, C; Locardi, E; Scharn, D; Richter, U; Kalkhof, H; Dinkel, K; Schnatbaum, K Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles. Bioorg Med Chem Lett 20:1229-32 (2010) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50309025
Synonyms:
CHEMBL603668 | N-(4-((5'-chloro-3,3'-difluoro-2'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methylamino)-1,2,5-oxadiazol-3-yl)-3-methoxyisoxazole-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H16ClF2N7O5
Mol. Mass.:
543.867
SMILES:
COc1cc(on1)C(=O)Nc1nonc1NCc1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Structure:
Search PDB for entries with ligand similarity: