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Target
B1 bradykinin receptor
Ligand
BDBM50309611
Substrate
n/a
Meas. Tech.
ChEMBL_610511 (CHEMBL1064982)
IC50
3.6±n/a nM
Citation
 Schnatbaum, K; Schaudt, M; Stragies, R; Pfeifer, JR; Gibson, C; Locardi, E; Scharn, D; Richter, U; Kalkhof, H; Dinkel, K; Zischinsky, G Novel small molecule bradykinin B1 receptor antagonists. Part 3: hydroxyurea derivatives. Bioorg Med Chem Lett 20:1233-6 (2010) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50309611
Synonyms:
(R)-3-(1-(5-(5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)-3-methylpyridin-2-yl)ethyl)-1-hydroxy-1-methylurea | CHEMBL598665
Type:
Small organic molecule
Emp. Form.:
C19H19ClFN5O3
Mol. Mass.:
419.837
SMILES:
C[C@@H](NC(=O)N(C)O)c1ncc(cc1C)-c1cc(Cl)cc(F)c1-c1noc(C)n1 |r|
Structure:
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