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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50310094
Substrate
n/a
Meas. Tech.
ChEMBL_612215 (CHEMBL1074153)
IC50
1±n/a nM
Citation
 Tsukada, T; Takahashi, M; Takemoto, T; Kanno, O; Yamane, T; Kawamura, S; Nishi, T Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg Med Chem Lett 20:1004-7 (2010) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50310094
Synonyms:
(7-carbamoyl-8H-indeno[1,2-d]thiazol-4-yloxy)methylphosphonic acid | CHEMBL589266 | {[(7-carbamoyl-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H11N2O5PS
Mol. Mass.:
326.265
SMILES:
NC(=O)c1ccc(OCP(O)(O)=O)c-2c1Cc1scnc-21
Structure:
Search PDB for entries with ligand similarity: