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Target
Beta-3 adrenergic receptor
Ligand
BDBM50311095
Substrate
n/a
Meas. Tech.
ChEMBL_619836 (CHEMBL1106713)
IC50
5200±n/a nM
Citation
 Pasternak, A; Goble, SD; deJesus, RK; Hreniuk, DL; Chung, CC; Tota, MR; Mazur, P; Feighner, SD; Howard, AD; Mills, SG; Yang, L Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists. Bioorg Med Chem Lett 19:6237-40 (2009) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50311095
Synonyms:
CHEMBL1079045 | N-(4-(2-amino-2-methylpropyl)phenyl)-4-(3-hexylureido)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H34N4O3S
Mol. Mass.:
446.606
SMILES:
CCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(CC(C)(C)N)cc1
Structure:
Search PDB for entries with ligand similarity: