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Target
Deoxycytidine kinase
Ligand
BDBM50311556
Substrate
n/a
Meas. Tech.
ChEMBL_618319 (CHEMBL1101183)
IC50
3±n/a nM
Citation
 Tarver, JE; Jessop, TC; Carlsen, M; Augeri, DJ; Fu, Q; Healy, JP; Heim-Riether, A; Xu, A; Taylor, JA; Shen, M; Keyes, PE; David Kimball, S; Yu, XC; Miranda, M; Liu, Q; Swaffield, JC; Nouraldeen, A; Wilson, AG; Finch, R; Jhaver, K; Foushee, AM; Anderson, S; Oravecz, T; Carson, KG 5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase. Bioorg Med Chem Lett 19:6780-3 (2009) [PubMed]  Article 
Target
Name:
Deoxycytidine kinase
Synonyms:
DCK | DCK_HUMAN
Type:
PROTEIN
Mol. Mass.:
30510.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1437135
Residue:
260
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
  
Inhibitor
Name:
BDBM50311556
Synonyms:
2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidin-1-yl)pyrimidin-4-yloxy)benzonitrile | CHEMBL1079906
Type:
Small organic molecule
Emp. Form.:
C20H18FN7O2
Mol. Mass.:
407.401
SMILES:
Nc1nc(OC2CCN(CC2)c2cc(Oc3ccccc3C#N)ncn2)ncc1F
Structure:
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