Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50312041
Substrate
n/a
Meas. Tech.
ChEMBL_620603 (CHEMBL1112064)
Ki
956±n/a nM
Citation
 Sun, ZY; Zhu, Z; Ye, Y; McKittrick, B; Czarniecki, M; Greenlee, W; Mullins, D; Guzzi, M Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists. Bioorg Med Chem Lett 19:6801-5 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50312041
Synonyms:
(+/-)-N-(4-(4-(2-chlorophenyl)-5,6-dihydro-4H-1,3-thiazin-2-ylamino)phenethyl)benzo[d]thiazol-2-amine | CHEMBL1081890
Type:
Small organic molecule
Emp. Form.:
C25H23ClN4S2
Mol. Mass.:
479.06
SMILES:
Clc1ccccc1C1CCSC(N1)=Nc1ccc(CCNc2nc3ccccc3s2)cc1 |w:13.15|
Structure:
Search PDB for entries with ligand similarity: