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Target
Tumor susceptibility gene 101 protein
Ligand
BDBM50312349
Substrate
n/a
Meas. Tech.
ChEMBL_619036 (CHEMBL1102078)
Kd
22000±n/a nM
Citation
 Liu, F; Stephen, AG; Waheed, AA; Freed, EO; Fisher, RJ; Burke, TR Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists. Bioorg Med Chem Lett 20:318-21 (2010) [PubMed]  Article 
Target
Name:
Tumor susceptibility gene 101 protein
Synonyms:
TS101_HUMAN | TSG101
Type:
PROTEIN
Mol. Mass.:
43943.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_800321
Residue:
390
Sequence:
MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
  
Inhibitor
Name:
BDBM50312349
Synonyms:
3,3'-((6S,28S,30aS,35aS,41S,44S,46aS)-26-(2-amino-2-oxoethyl)-10-(5-(3-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-yl)thioureido)pentanoyl)-44-((R)-1-hydroxyethyl)-41-methyl-5,8,27,30,35,40,43,46-octaoxo-1,2,3,5,6,7,8,9,10,11,12,13,14,17,18,19,20,21,22,23,24,25,26,27,28,29,30,30a,31,32,33,35,35a,36,37,38,40,41,42,43,44,45,46,46a-tetratetracontahydrotripyrrolo[2,1-f:2',1'-i:2'',1''-r][1,4,7,10,13,16,19,22,25]nonaazacyclotetracontine-6,28-diyl)dipropanoic acid | CHEMBL1075918
Type:
Small organic molecule
Emp. Form.:
C77H102N12O20S
Mol. Mass.:
1547.767
SMILES:
C[C@@H](O)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(O)=O)NC(=O)CN(CCCC\C=C/CCCCCCCCCN(CC(N)=O)C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)CCCCNC(=S)Nc1ccc2C(=O)OC3(c2c1)c1ccc(O)cc1Oc1cc(O)ccc31 |r,c:30|
Structure:
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