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Target
Cyclin-dependent kinase 2
Ligand
BDBM50312932
Substrate
n/a
Meas. Tech.
ChEMBL_615909 (CHEMBL1102923)
IC50
55±n/a nM
Citation
 Zeng, Q; Allen, JG; Bourbeau, MP; Wang, X; Yao, G; Tadesse, S; Rider, JT; Yuan, CC; Hong, FT; Lee, MR; Zhang, S; Lofgren, JA; Freeman, DJ; Yang, S; Li, C; Tominey, E; Huang, X; Hoffman, D; Yamane, HK; Fotsch, C; Dominguez, C; Hungate, R; Zhang, X Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorg Med Chem Lett 20:1559-64 (2010) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50312932
Synonyms:
(S)-N1-(5-(1-amino-1H-benzo[d][1,2,3]triazol-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | CHEMBL1081830
Type:
Small organic molecule
Emp. Form.:
C19H18F3N7S
Mol. Mass.:
433.453
SMILES:
N[C@H](CNc1ncc(s1)-c1ccc2nnn(N)c2c1)Cc1ccc(cc1)C(F)(F)F |r|
Structure:
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