Reaction Details Report a problem with these data
Target
Thymidine phosphorylase
Ligand
BDBM50313094
Substrate
n/a
Meas. Tech.
ChEMBL_616439 (CHEMBL1100898)
Ki
17±n/a nM
Citation
 Jain, HV; Rasheed, R; Kalman, TI The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett 20:1648-51 (2010) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase
Type:
Enzyme
Mol. Mass.:
49948.87
Organism:
Homo sapiens (Human)
Description:
The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:
482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
  
Inhibitor
Name:
BDBM50313094
Synonyms:
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil | CHEMBL1080896
Type:
Small organic molecule
Emp. Form.:
C8H8FN5O2
Mol. Mass.:
225.1798
SMILES:
Nc1nccn1Cc1[nH]c(=O)[nH]c(=O)c1F
Structure:
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