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Target
Serine/threonine-protein kinase NLK
Ligand
BDBM50314070
Substrate
n/a
Meas. Tech.
ChEMBL_627168 (CHEMBL1111810)
Kd
170±n/a nM
Citation
 Goldstein, DM; Kuglstatter, A; Lou, Y; Soth, MJ Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem 53:2345-53 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase NLK
Synonyms:
LAK1 | NLK | NLK_HUMAN | Serine/threonine protein kinase NLK
Type:
PROTEIN
Mol. Mass.:
58306.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774580
Residue:
527
Sequence:
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
  
Inhibitor
Name:
BDBM50314070
Synonyms:
6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | CHEMBL1090089 | pamapimod
Type:
Small organic molecule
Emp. Form.:
C19H20F2N4O4
Mol. Mass.:
406.3833
SMILES:
Cn1c2nc(NC(CCO)CCO)ncc2cc(Oc2ccc(F)cc2F)c1=O
Structure:
Search PDB for entries with ligand similarity: