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Target
Baculoviral IAP repeat-containing protein 7
Ligand
BDBM50314451
Substrate
n/a
Meas. Tech.
ChEMBL_624591 (CHEMBL1111551)
Ki
40000±n/a nM
Citation
 Cohen, F; Koehler, MF; Bergeron, P; Elliott, LO; Flygare, JA; Franklin, MC; Gazzard, L; Keteltas, SF; Lau, K; Ly, CQ; Tsui, V; Fairbrother, WJ Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg Med Chem Lett 20:2229-33 (2010) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 7
Synonyms:
BIR3 | BIRC7 | BIRC7_HUMAN | Baculoviral IAP repeat-containing protein 7 | KIAP | LIVIN | MLIAP | RNF50
Type:
PROTEIN
Mol. Mass.:
32792.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_624591
Residue:
298
Sequence:
MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCRAWDHVDGQILGQLRPLTEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEPEDAAPVAPSVPASGYPELPTPRREVQSESAQEPGGVSPAEAQRAWWVLEPPGARDVEAQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQLCPICRAPVRSRVRTFLS
  
Inhibitor
Name:
BDBM50314451
Synonyms:
(S)-N-((S)-2-((S)-2-(4-(4-fluoronaphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide | CHEMBL1089024
Type:
Small organic molecule
Emp. Form.:
C28H33FN4O3S
Mol. Mass.:
524.65
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1CCC[C@H]1c1nc(cs1)-c1ccc(F)c2ccccc12 |r|
Structure:
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