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Target
Orexin receptor type 2
Ligand
BDBM50314677
Substrate
n/a
Meas. Tech.
ChEMBL_625830 (CHEMBL1109766)
Ki
3.60±n/a nM
Citation
 Coleman, PJ; Schreier, JD; McGaughey, GB; Bogusky, MJ; Cox, CD; Hartman, GD; Ball, RG; Harrell, CM; Reiss, DR; Prueksaritanont, T; Winrow, CJ; Renger, JJ Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists. Bioorg Med Chem Lett 20:2311-5 (2010) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50314677
Synonyms:
(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)(6-(quinazolin-2-yl)-3,6-diazabicyclo[3.2.1]octan-3-yl)methanone | CHEMBL1091110
Type:
Small organic molecule
Emp. Form.:
C24H23N7O
Mol. Mass.:
425.4857
SMILES:
Cc1ccc(c(c1)C(=O)N1CC2CC(C1)N(C2)c1ncc2ccccc2n1)-n1nccn1
Structure:
Search PDB for entries with ligand similarity: