Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50314775
Substrate
n/a
Meas. Tech.
ChEMBL_626765 (CHEMBL1106334)
Ki
14±n/a nM
Citation
 Vullo, D; Nishimori, I; Scozzafava, A; Köhler, S; Winum, JY; Supuran, CT Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides. Bioorg Med Chem Lett 20:2178-82 (2010) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50314775
Synonyms:
4-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-ylamino)benzenesulfonamide | CHEMBL1090524
Type:
Small organic molecule
Emp. Form.:
C12H18N2O6S
Mol. Mass.:
318.346
SMILES:
C[C@H]1O[C@@H](Nc2ccc(cc2)S(N)(=O)=O)[C@H](O)[C@@H](O)[C@H]1O |r|
Structure:
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