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Target
Deoxynucleoside kinase
Ligand
BDBM50314846
Substrate
n/a
Meas. Tech.
ChEMBL_627484 (CHEMBL1111770)
IC50
>500000±n/a nM
Citation
 Van Poecke, S; Negri, A; Gago, F; Van Daele, I; Solaroli, N; Karlsson, A; Balzarini, J; Van Calenbergh, S 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem 53:2902-12 (2010) [PubMed]  Article 
Target
Name:
Deoxynucleoside kinase
Synonyms:
DNK_DROME | Deoxyribonucleoside kinase | Dm-dNK | Multispecific deoxynucleoside kinase | dnk
Type:
PROTEIN
Mol. Mass.:
29092.93
Organism:
Drosophila melanogaster
Description:
ChEMBL_627484
Residue:
250
Sequence:
MAEAASCARKGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDADLNLENIGTEYQRSESSIFDAISSNQQPSPVLVSPSKRQRVAR
  
Inhibitor
Name:
BDBM50314846
Synonyms:
1-(3'-Deoxy-5'-O-triphenylmethyl-beta-D-thymidin-3'-yl)-3-(4-chloro-3-(trifluoromethyl)-phenyl)-thiourea | CHEMBL1092055
Type:
Small organic molecule
Emp. Form.:
C37H32ClF3N4O4S
Mol. Mass.:
721.188
SMILES:
Cc1cn([C@H]2C[C@H](NC(=S)Nc3ccc(Cl)c(c3)C(F)(F)F)[C@@H](COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)[nH]c1=O |r|
Structure:
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