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Target
Aurora kinase B
Ligand
BDBM50315774
Substrate
n/a
Meas. Tech.
ChEMBL_624529 (CHEMBL1110578)
IC50
169±n/a nM
Citation
 Medina, JR; Grant, SW; Axten, JM; Miller, WH; Donatelli, CA; Hardwicke, MA; Oleykowski, CA; Liao, Q; Plant, R; Xiang, H Discovery of a new series of Aurora inhibitors through truncation of GSK1070916. Bioorg Med Chem Lett 20:2552-5 (2010) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50315774
Synonyms:
CHEMBL1090508 | N,N-dimethyl-1-(4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl)methanamine
Type:
Small organic molecule
Emp. Form.:
C20H21N5
Mol. Mass.:
331.4142
SMILES:
CN(C)Cc1ccc(cc1)-c1cc2c(ccnc2[nH]1)-c1cnn(C)c1
Structure:
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