Reaction Details Report a problem with these data
Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM50266759
Substrate
n/a
Meas. Tech.
ChEMBL_624968 (CHEMBL1108824)
IC50
100±n/a nM
Citation
 Hu, GX; Liang, G; Chu, Y; Li, X; Lian, QQ; Lin, H; He, Y; Huang, Y; Hardy, DO; Ge, RS Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg Med Chem Lett 20:2549-51 (2010) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
DHB3_RAT | Edh17b3 | Hsd17b3 | Testosterone 17-beta-dehydrogenase 3
Type:
PROTEIN
Mol. Mass.:
34235.73
Organism:
Rattus norvegicus
Description:
ChEMBL_1510493
Residue:
306
Sequence:
MEQFLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQVISEEIERTTGSRVKVVQADFTREDIYDHIEEQLKGLEIGVLVNNVGMLPNLLPSHFLSTSGESQSVIHCNITSVVKMTQLVLKHMESRRRGLILNISSGVGVRPWPLYSLYSASKAFVCTFSKALNVEYRDKGIIIQVLTPYSVSTPMTKYLNTSRVTKTADEFVKESLKYVTIGAETCGCLAHEILAIILNLIPSRIFYSSTTQRFLLKQFSDYLKSNISNR
  
Inhibitor
Name:
BDBM50266759
Synonyms:
(1E,4E)-1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one | 1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one | CHEMBL476220
Type:
Small organic molecule
Emp. Form.:
C17H12F2O
Mol. Mass.:
270.2734
SMILES:
Fc1ccc(\C=C\C(=O)\C=C\c2ccc(F)cc2)cc1
Structure:
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