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Target
Translocator protein
Ligand
BDBM50316601
Substrate
n/a
Meas. Tech.
ChEMBL_631761 (CHEMBL1114782)
Kd
5.07±n/a nM
Citation
 Taliani, S; Da Pozzo, E; Bellandi, M; Bendinelli, S; Pugliesi, I; Simorini, F; La Motta, C; Salerno, S; Marini, AM; Da Settimo, F; Cosimelli, B; Greco, G; Novellino, E; Martini, C Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization. J Med Chem 53:4085-93 (2010) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50316601
Synonyms:
CHEMBL1097503 | N,N-Dihexyl-[5-isothiocyanato-2-phenylindol-3-yl)glyoxylamide
Type:
Small organic molecule
Emp. Form.:
C29H35N3O2S
Mol. Mass.:
489.672
SMILES:
CCCCCCN(CCCCCC)C(=O)C(=O)c1c([nH]c2ccc(cc12)N=C=S)-c1ccccc1
Structure:
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