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Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM50316637
Substrate
n/a
Meas. Tech.
ChEMBL_632023 (CHEMBL1110065)
IC50
0.43±n/a nM
Citation
 Sun, H; Liu, L; Lu, J; Qiu, S; Yang, CY; Yi, H; Wang, S Cyclopeptide Smac mimetics as antagonists of IAP proteins. Bioorg Med Chem Lett 20:3043-6 (2010) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Homo sapiens (Human)
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM50316637
Synonyms:
(2S)-2-(methylamino)-N-[(2S,5S,11S,20S,23S,29S)-29-[(2S)-2-(methylamino)propanamido]-4,10,22,28-tetraoxo-2,20-diphenyl-3,9,16,17,18,21,27,34,35,36-decaazapentacyclo[32.2.1.1^{16,19}.0^{5,9}.0^{23,27}]octatriaconta-1(37),17,19(38),35-tetraen-11-yl]propanamide | CHEMBL1095993
Type:
Small organic molecule
Emp. Form.:
C48H66N14O6
Mol. Mass.:
935.1278
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CCCCn2cc(nn2)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCn2cc(nn2)[C@@H](NC(=O)[C@@H]2CCCN2C1=O)c1ccccc1)NC(=O)[C@H](C)NC)c1ccccc1 |r|
Structure:
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