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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50316957
Substrate
n/a
Meas. Tech.
ChEMBL_630104 (CHEMBL1110024)
Ki
93±n/a nM
Citation
 Yan, Y; Zhou, P; Rotella, DP; Feenstra, R; Kruse, CG; Reinders, JH; van der Neut, M; Lai, M; Zhang, J; Kowal, DM; Carrick, T; Marquis, KL; Pausch, MH; Robichaud, AJ Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia. Bioorg Med Chem Lett 20:2983-6 (2010) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50316957
Synonyms:
7-(4-(3-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)propyl)piperazin-1-yl)benzo[d]oxazol-2(3H)-one | CHEMBL1087453
Type:
Small organic molecule
Emp. Form.:
C23H26N4O4
Mol. Mass.:
422.4769
SMILES:
O=C1CCc2ccc(OCCCN3CCN(CC3)c3cccc4[nH]c(=O)oc34)cc2N1
Structure:
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