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Target
Protein-tyrosine-phosphatase
Ligand
BDBM50317073
Substrate
n/a
Meas. Tech.
ChEMBL_630353 (CHEMBL1112875)
IC50
2400±n/a nM
Citation
 Liu, F; Hakami, RM; Dyas, B; Bahta, M; Lountos, GT; Waugh, DS; Ulrich, RG; Burke, TR A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH. Bioorg Med Chem Lett 20:2813-6 (2010) [PubMed]  Article 
Target
Name:
Protein-tyrosine-phosphatase
Synonyms:
Secreted effector protein | Secreted protein-tyrosine phosphatase
Type:
PROTEIN
Mol. Mass.:
50881.86
Organism:
Yersinia pestis
Description:
ChEMBL_810616
Residue:
468
Sequence:
MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANVVLTQEDTAKLLQSTVKHNLNNYDLRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSALHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVGDDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
  
Inhibitor
Name:
BDBM50317073
Synonyms:
16-(4-(benzyloxy)phenyl)-3,14-dioxa-2,15-diazahexadeca-1,15-dienyl)-2-hydroxybenzoic acid | CHEMBL1088248
Type:
Small organic molecule
Emp. Form.:
C32H38N2O6
Mol. Mass.:
546.6539
SMILES:
OC(=O)c1cc(\C=N\OCCCCCCCCCCO\N=C\c2ccc(OCc3ccccc3)cc2)ccc1O
Structure:
Search PDB for entries with ligand similarity: