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Target
Cholinesterase
Ligand
BDBM50317189
Substrate
n/a
Meas. Tech.
ChEMBL_631312 (CHEMBL1105649)
IC50
652±n/a nM
Citation
 Rook, Y; Schmidtke, KU; Gaube, F; Schepmann, D; Wünsch, B; Heilmann, J; Lehmann, J; Winckler, T Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem 53:3611-7 (2010) [PubMed]  Article 
Target
Name:
Cholinesterase
Synonyms:
BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase
Type:
Enzyme
Mol. Mass.:
65643.35
Organism:
Equus caballus (Horse)
Description:
P81908
Residue:
574
Sequence:
EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNPNGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
  
Inhibitor
Name:
BDBM50317189
Synonyms:
2-[3-(beta-Carboline-2-ium-2-yl)propyl]-beta-carboline-2-ium dibromide | CHEMBL1088224
Type:
Small organic molecule
Emp. Form.:
C25H22N4
Mol. Mass.:
378.4679
SMILES:
C(C[n+]1ccc2c(c1)[nH]c1ccccc21)C[n+]1ccc2c(c1)[nH]c1ccccc21
Structure:
Search PDB for entries with ligand similarity: