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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50065788
Substrate
n/a
Meas. Tech.
ChEMBL_631598 (CHEMBL1106592)
IC50
3100±n/a nM
Citation
 Sliman, F; Blairvacq, M; Durieu, E; Meijer, L; Rodrigo, J; Desmaële, D Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett 20:2801-5 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50065788
Synonyms:
(E)-2-(3-carboxy-4-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-(3-carboxy-4-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-[(E)-2-(3-Carboxy-4-hydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | 2-[2-(3-Carboxy-4-hydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | CHEMBL59548
Type:
Small organic molecule
Emp. Form.:
C19H13NO6
Mol. Mass.:
351.3096
SMILES:
OC(=O)c1ccc2ccc(\C=C\c3ccc(O)c(c3)C(O)=O)nc2c1O
Structure:
Search PDB for entries with ligand similarity: