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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50317354
Substrate
n/a
Meas. Tech.
ChEMBL_631610 (CHEMBL1106604)
IC50
18600±n/a nM
Citation
 Chen, HJ; Liu, Y; Wang, LN; Shen, Q; Li, J; Nan, FJ Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B. Bioorg Med Chem Lett 20:2876-9 (2010) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50317354
Synonyms:
CHEMBL1097390 | methyl 3-(3-stearoyl-1H-pyrazole-5-carboxamido)thiophene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C28H43N3O4S
Mol. Mass.:
517.724
SMILES:
CCCCCCCCCCCCCCCCCC(=O)c1cc([nH]n1)C(=O)Nc1ccsc1C(=O)OC
Structure:
Search PDB for entries with ligand similarity: