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Target
M-phase inducer phosphatase 2
Ligand
BDBM50317367
Substrate
n/a
Meas. Tech.
ChEMBL_631608 (CHEMBL1106602)
IC50
1010±n/a nM
Citation
 Chen, HJ; Liu, Y; Wang, LN; Shen, Q; Li, J; Nan, FJ Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B. Bioorg Med Chem Lett 20:2876-9 (2010) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50317367
Synonyms:
5-(3-bromophenyl)-3-stearoylpyrrolo[3,4-c]pyrazole-4,6(1H,5H)-dione | CHEMBL1095551
Type:
Small organic molecule
Emp. Form.:
C29H40BrN3O3
Mol. Mass.:
558.55
SMILES:
CCCCCCCCCCCCCCCCCC(=O)c1n[nH]c2C(=O)N(C(=O)c12)c1cccc(Br)c1
Structure:
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