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Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM50318026
Substrate
n/a
Meas. Tech.
ChEMBL_631133 (CHEMBL1107397)
EC50
1.4±n/a nM
Citation
 Calleri, E; Ceruti, S; Cristalli, G; Martini, C; Temporini, C; Parravicini, C; Volpini, R; Daniele, S; Caccialanza, G; Lecca, D; Lambertucci, C; Trincavelli, ML; Marucci, G; Wainer, IW; Ranghino, G; Fantucci, P; Abbracchio, MP; Massolini, G Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. J Med Chem 53:3489-501 (2010) [PubMed]  Article 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
GPR17 | GPR17_HUMAN
Type:
PROTEIN
Mol. Mass.:
41013.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1353471
Residue:
367
Sequence:
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
  
Inhibitor
Name:
BDBM50318026
Synonyms:
((2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyltriphosphate tetraammonium salt | CHEMBL1096742
Type:
Small organic molecule
Emp. Form.:
C15H24N5O13P3
Mol. Mass.:
575.298
SMILES:
O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(NC3CCCC3)ncnc12 |r|
Structure:
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