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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50318039
Substrate
n/a
Meas. Tech.
ChEMBL_631195 (CHEMBL1110044)
IC50
>200000±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM50318039
Synonyms:
4-bromo-2-(2,6-dichlorophenyl)-5-(4-fluorobenzyloxy)pyridazin-3(2H)-one | CHEMBL1096092
Type:
Small organic molecule
Emp. Form.:
C17H10BrCl2FN2O2
Mol. Mass.:
444.082
SMILES:
Fc1ccc(COc2cnn(-c3c(Cl)cccc3Cl)c(=O)c2Br)cc1 |(4.96,-22.83,;6.3,-23.59,;7.63,-22.82,;8.97,-23.59,;8.96,-25.13,;10.29,-25.9,;11.63,-25.13,;12.96,-25.9,;14.29,-25.13,;15.62,-25.9,;15.63,-27.45,;16.96,-28.21,;18.28,-27.44,;18.28,-25.9,;19.62,-28.2,;19.62,-29.75,;18.29,-30.52,;16.96,-29.75,;15.62,-30.52,;14.29,-28.22,;14.29,-29.76,;12.96,-27.45,;11.62,-28.21,;7.64,-25.9,;6.3,-25.14,)|
Structure:
Search PDB for entries with ligand similarity: