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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50318043
Substrate
n/a
Meas. Tech.
ChEMBL_631195 (CHEMBL1110044)
IC50
>200000±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM50318043
Synonyms:
4-bromo-2-(2,6-dichlorophenyl)-5-(3,4-difluorobenzyloxy)pyridazin-3(2H)-one | CHEMBL1095304
Type:
Small organic molecule
Emp. Form.:
C17H9BrCl2F2N2O2
Mol. Mass.:
462.072
SMILES:
Fc1ccc(COc2cnn(-c3c(Cl)cccc3Cl)c(=O)c2Br)cc1F |(22.41,-32.44,;23.74,-33.21,;25.08,-32.44,;26.41,-33.21,;26.41,-34.75,;27.74,-35.52,;29.07,-34.75,;30.41,-35.52,;31.73,-34.75,;33.07,-35.51,;33.08,-37.06,;34.4,-37.83,;35.73,-37.06,;35.72,-35.52,;37.06,-37.82,;37.07,-39.37,;35.74,-40.14,;34.4,-39.37,;33.07,-40.14,;31.74,-37.83,;31.74,-39.37,;30.4,-37.06,;29.07,-37.83,;25.08,-35.52,;23.75,-34.76,;22.42,-35.53,)|
Structure:
Search PDB for entries with ligand similarity: