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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50318045
Substrate
n/a
Meas. Tech.
ChEMBL_631195 (CHEMBL1110044)
IC50
>200000±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM50318045
Synonyms:
4-bromo-5-(4-chloro-2-fluorobenzyloxy)-2-(2,6-dichlorophenyl)pyridazin-3(2H)-one | CHEMBL1098756
Type:
Small organic molecule
Emp. Form.:
C17H9BrCl3FN2O2
Mol. Mass.:
478.527
SMILES:
Fc1cc(Cl)ccc1COc1cnn(-c2c(Cl)cccc2Cl)c(=O)c1Br |(10.55,-47.08,;10.55,-45.54,;9.21,-44.78,;9.21,-43.23,;7.87,-42.46,;10.54,-42.46,;11.88,-43.23,;11.87,-44.77,;13.2,-45.54,;14.54,-44.77,;15.87,-45.54,;17.2,-44.77,;18.54,-45.53,;18.54,-47.08,;19.87,-47.85,;21.2,-47.08,;21.19,-45.54,;22.53,-47.84,;22.54,-49.39,;21.2,-50.16,;19.87,-49.39,;18.54,-50.16,;17.2,-47.85,;17.2,-49.39,;15.87,-47.08,;14.54,-47.85,)|
Structure:
Search PDB for entries with ligand similarity: