Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Mitogen-activated protein kinase 9
Ligand
BDBM50318046
Substrate
n/a
Meas. Tech.
ChEMBL_631195 (CHEMBL1110044)
IC50
>200000±n/a nM
Citation
Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed] Article More Info.:
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
Inhibitor
Name:
BDBM50318046
Synonyms:
4-bromo-2-(3,5-dichloropyridin-4-yl)-5-(2,4-difluorobenzyloxy)pyridazin-3(2H)-one | CHEMBL1098757
Type:
Small organic molecule
Emp. Form.:
C16H8BrCl2F2N3O2
Mol. Mass.:
463.06
SMILES:
Fc1ccc(COc2cnn(-c3c(Cl)cncc3Cl)c(=O)c2Br)c(F)c1 |(22.4,-41.65,;23.74,-42.42,;25.07,-41.65,;26.41,-42.42,;26.4,-43.96,;27.73,-44.73,;29.07,-43.96,;30.4,-44.73,;31.73,-43.96,;33.06,-44.72,;33.07,-46.27,;34.4,-47.04,;35.72,-46.27,;35.72,-44.73,;37.06,-47.03,;37.07,-48.58,;35.73,-49.35,;34.4,-48.58,;33.07,-49.35,;31.73,-47.05,;31.73,-48.59,;30.4,-46.27,;29.06,-47.04,;25.08,-44.73,;25.08,-46.27,;23.74,-43.97,)|
Structure:
