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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50318035
Substrate
n/a
Meas. Tech.
ChEMBL_631194 (CHEMBL1110043)
IC50
1390±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50318035
Synonyms:
5-(benzyloxy)-4-bromo-2-(2,6-dichlorophenyl)pyridazin-3(2H)-one | CHEMBL1094983
Type:
Small organic molecule
Emp. Form.:
C17H11BrCl2N2O2
Mol. Mass.:
426.091
SMILES:
Clc1cccc(Cl)c1-n1ncc(OCc2ccccc2)c(Br)c1=O |(1.93,-16.96,;1.94,-18.5,;3.27,-19.26,;3.28,-20.81,;1.95,-21.58,;.61,-20.82,;-.72,-21.59,;.61,-19.27,;-.72,-18.51,;-.72,-16.96,;-2.06,-16.19,;-3.39,-16.96,;-4.72,-16.19,;-6.05,-16.96,;-7.39,-16.19,;-7.38,-14.65,;-8.71,-13.88,;-10.05,-14.65,;-10.04,-16.2,;-8.71,-16.96,;-3.39,-18.51,;-4.72,-19.28,;-2.05,-19.28,;-2.05,-20.82,)|
Structure:
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