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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50318036
Substrate
n/a
Meas. Tech.
ChEMBL_631194 (CHEMBL1110043)
IC50
5720±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50318036
Synonyms:
5-(benzylamino)-4-bromo-2-(2,6-dichlorophenyl)pyridazin-3(2H)-one | CHEMBL1095775
Type:
Small organic molecule
Emp. Form.:
C17H12BrCl2N3O
Mol. Mass.:
425.107
SMILES:
Clc1cccc(Cl)c1-n1ncc(NCc2ccccc2)c(Br)c1=O |(17.67,-16.85,;17.67,-18.39,;19.01,-19.15,;19.01,-20.69,;17.68,-21.47,;16.35,-20.7,;15.01,-21.47,;16.35,-19.16,;15.02,-18.39,;15.01,-16.84,;13.68,-16.08,;12.35,-16.85,;11.01,-16.08,;9.68,-16.85,;8.35,-16.08,;8.35,-14.54,;7.02,-13.77,;5.69,-14.54,;5.69,-16.09,;7.02,-16.85,;12.35,-18.39,;11.01,-19.16,;13.68,-19.16,;13.68,-20.7,)|
Structure:
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