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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50318038
Substrate
n/a
Meas. Tech.
ChEMBL_631194 (CHEMBL1110043)
IC50
3810±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50318038
Synonyms:
4-bromo-2-(2,6-dichlorophenyl)-5-(phenethylamino)pyridazin-3(2H)-one | CHEMBL1096091
Type:
Small organic molecule
Emp. Form.:
C18H14BrCl2N3O
Mol. Mass.:
439.133
SMILES:
Clc1cccc(Cl)c1-n1ncc(NCCc2ccccc2)c(Br)c1=O |(2.65,-25.17,;2.66,-26.71,;4,-27.47,;4,-29.02,;2.67,-29.79,;1.34,-29.02,;0,-29.79,;1.34,-27.48,;.01,-26.71,;0,-25.16,;-1.33,-24.4,;-2.66,-25.17,;-4,-24.4,;-5.33,-25.17,;-6.66,-24.4,;-8,-25.17,;-9.33,-24.4,;-10.66,-25.17,;-10.66,-26.71,;-9.32,-27.48,;-7.99,-26.7,;-2.66,-26.71,;-4,-27.48,;-1.33,-27.48,;-1.33,-29.02,)|
Structure:
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