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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50318040
Substrate
n/a
Meas. Tech.
ChEMBL_631194 (CHEMBL1110043)
IC50
12300±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50318040
Synonyms:
4-bromo-2-(2,6-dichlorophenyl)-5-(4-fluorobenzylamino)pyridazin-3(2H)-one | CHEMBL1095142
Type:
Small organic molecule
Emp. Form.:
C17H11BrCl2FN3O
Mol. Mass.:
443.097
SMILES:
Fc1ccc(CNc2cnn(-c3c(Cl)cccc3Cl)c(=O)c2Br)cc1 |(20.13,-21.95,;21.47,-22.72,;22.8,-21.95,;24.13,-22.72,;24.13,-24.26,;25.46,-25.03,;26.8,-24.26,;28.13,-25.03,;29.46,-24.26,;30.79,-25.02,;30.8,-26.57,;32.13,-27.34,;33.45,-26.57,;33.45,-25.03,;34.79,-27.33,;34.79,-28.88,;33.46,-29.65,;32.13,-28.88,;30.79,-29.65,;29.46,-27.34,;29.46,-28.88,;28.13,-26.57,;26.79,-27.34,;22.81,-25.03,;21.47,-24.27,)|
Structure:
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