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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50318041
Substrate
n/a
Meas. Tech.
ChEMBL_631194 (CHEMBL1110043)
IC50
160±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50318041
Synonyms:
4-bromo-2-(2,6-dichlorophenyl)-5-(2,4-difluorobenzyloxy)pyridazin-3(2H)-one | CHEMBL1096436
Type:
Small organic molecule
Emp. Form.:
C17H9BrCl2F2N2O2
Mol. Mass.:
462.072
SMILES:
Fc1ccc(COc2cnn(-c3c(Cl)cccc3Cl)c(=O)c2Br)c(F)c1 |(-10.18,-31.86,;-8.85,-32.63,;-7.51,-31.86,;-6.18,-32.63,;-6.19,-34.17,;-4.86,-34.94,;-3.52,-34.17,;-2.19,-34.94,;-.86,-34.17,;.48,-34.93,;.48,-36.48,;1.81,-37.25,;3.14,-36.47,;3.13,-34.93,;4.47,-37.24,;4.48,-38.78,;3.14,-39.56,;1.81,-38.79,;.48,-39.56,;-.86,-37.25,;-.86,-38.79,;-2.19,-36.48,;-3.52,-37.25,;-7.51,-34.94,;-7.51,-36.48,;-8.84,-34.17,)|
Structure:
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