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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50318042
Substrate
n/a
Meas. Tech.
ChEMBL_631194 (CHEMBL1110043)
IC50
540±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50318042
Synonyms:
4-bromo-2-(2,6-dichlorophenyl)-5-(2,4,6-trifluorobenzyloxy)pyridazin-3(2H)-one | CHEMBL1096437
Type:
Small organic molecule
Emp. Form.:
C17H8BrCl2F3N2O2
Mol. Mass.:
480.063
SMILES:
Fc1cc(F)c(COc2cnn(-c3c(Cl)cccc3Cl)c(=O)c2Br)c(F)c1 |(6.2,-32.89,;7.54,-33.66,;7.54,-35.2,;8.88,-35.97,;8.88,-37.51,;10.2,-35.2,;11.53,-35.97,;12.87,-35.19,;14.2,-35.96,;15.53,-35.19,;16.86,-35.96,;16.87,-37.51,;18.2,-38.27,;19.52,-37.5,;19.52,-35.96,;20.86,-38.26,;20.86,-39.81,;19.53,-40.58,;18.2,-39.82,;16.86,-40.59,;15.53,-38.28,;15.53,-39.82,;14.2,-37.51,;12.86,-38.28,;10.2,-33.65,;11.54,-32.89,;8.87,-32.88,)|
Structure:
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