Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50318044
Substrate
n/a
Meas. Tech.
ChEMBL_631194 (CHEMBL1110043)
IC50
470±n/a nM
Citation
 Jerome, KD; Hepperle, ME; Walker, JK; Xing, L; Devraj, RV; Benson, AG; Baldus, JE; Selness, SR Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 20:3146-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50318044
Synonyms:
4-bromo-2-(2,6-dichlorophenyl)-5-(2,3,4-trifluorobenzyloxy)pyridazin-3(2H)-one | CHEMBL1096438
Type:
Small organic molecule
Emp. Form.:
C17H8BrCl2F3N2O2
Mol. Mass.:
480.063
SMILES:
Fc1ccc(COc2cnn(-c3c(Cl)cccc3Cl)c(=O)c2Br)c(F)c1F |(-10.45,-42.22,;-9.12,-42.99,;-7.78,-42.22,;-6.45,-42.99,;-6.45,-44.53,;-5.12,-45.3,;-3.79,-44.53,;-2.45,-45.3,;-1.12,-44.53,;.21,-45.29,;.22,-46.84,;1.55,-47.61,;2.87,-46.84,;2.86,-45.3,;4.21,-47.6,;4.21,-49.15,;2.88,-49.92,;1.55,-49.15,;.21,-49.92,;-1.12,-47.61,;-1.12,-49.15,;-2.45,-46.84,;-3.79,-47.61,;-7.78,-45.3,;-7.77,-46.84,;-9.11,-44.54,;-10.44,-45.31,)|
Structure:
Search PDB for entries with ligand similarity: