Reaction Details Report a problem with these data
Target
HTH-type transcriptional regulator ExsA
Ligand
BDBM50319084
Substrate
n/a
Meas. Tech.
ChEMBL_635526 (CHEMBL1118109)
IC50
>100000±n/a nM
Citation
Grier, MC; Garrity-Ryan, LK; Bartlett, VJ; Klausner, KA; Donovan, PJ; Dudley, C; Alekshun, MN; Tanaka, SK; Draper, MP; Levy, SB; Kim, OK N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability. Bioorg Med Chem Lett 20:3380-3 (2010) [PubMed] Article
More Info.:
Target
Name:
HTH-type transcriptional regulator ExsA
Synonyms:
EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA
Type:
PROTEIN
Mol. Mass.:
31648.37
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_635526
Residue:
278
Sequence:
MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVRRGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAGCVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKHYLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
Inhibitor
Name:
BDBM50319084
Synonyms:
(E)-N-(4-(1-hydroxy-6-nitro-1H-benzo[d]imidazol-2-yl)phenyl)-3-(4-(2,2,2-trifluoro-1,1-dihydroxyethyl)phenyl)acrylamide | CHEMBL1084626
Type:
Small organic molecule
Emp. Form.:
C24H17F3N4O6
Mol. Mass.:
514.4102
SMILES:
On1c(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(NC(=O)\C=C\c2ccc(cc2)C(O)(O)C(F)(F)F)cc1