Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50319109
Substrate
n/a
Meas. Tech.
ChEMBL_635633 (CHEMBL1119525)
EC50
17±n/a nM
Citation
 Schmidt, D; Smenton, A; Raghavan, S; Shen, H; Ding, FX; Carballo-Jane, E; Luell, S; Ciecko, T; Holt, TG; Wolff, M; Taggart, A; Wilsie, L; Krsmanovic, M; Ren, N; Blom, D; Cheng, K; McCann, PE; Waters, MG; Tata, J; Colletti, S Anthranilic acid replacements in a niacin receptor agonist. Bioorg Med Chem Lett 20:3426-30 (2010) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50319109
Synonyms:
2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)propanamido)-5-propylcyclohex-1-enecarboxylic acid | CHEMBL1084576
Type:
Small organic molecule
Emp. Form.:
C20H24N4O5
Mol. Mass.:
400.4284
SMILES:
CCCC1CCC(NC(=O)CCc2nc(no2)-c2ccc(O)cn2)=C(C1)C(O)=O |c:25|
Structure:
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