Reaction Details
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11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50319310
Substrate
n/a
Meas. Tech.
ChEMBL_634029 (CHEMBL1118158)
IC50
252±n/a nM
Citation
Webster, SP; Binnie, M; McConnell, KM; Sooy, K; Ward, P; Greaney, MF; Vinter, A; Pallin, TD; Dyke, HJ; Gill, MI; Warner, I; Seckl, JR; Walker, BR Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles. Bioorg Med Chem Lett 20:3265-71 (2010) [PubMed] Article More Info.:
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Inhibitor
Name:
BDBM50319310
Synonyms:
3,3-dimethyl-1-(1-phenyl-1H-tetrazol-5-ylthio)butan-2-one | CHEMBL1083161
Type:
Small organic molecule
Emp. Form.:
C14H17N3OS
Mol. Mass.:
275.369
SMILES:
CC(C)(C)C(=O)CSc1cnnn1-c1ccccc1
Structure:
