Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50319490
Substrate
n/a
Meas. Tech.
ChEMBL_634234 (CHEMBL1120181)
Ki
7800±n/a nM
Citation
 Tumey, LN; Robarge, MJ; Gleason, E; Song, J; Murphy, SM; Ekema, G; Doucette, C; Hanniford, D; Palmer, M; Pawlowski, G; Danzig, J; Loftus, M; Hunady, K; Sherf, B; Mays, RW; Stricker-Krongrad, A; Brunden, KR; Bennani, YL; Harrington, JJ 3-Indolyl sultams as selective CRTh2 antagonists. Bioorg Med Chem Lett 20:3287-90 (2010) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50319490
Synonyms:
CHEMBL1084903 | rac-{3-[1,1-Dioxo-2-(2-phenoxy-ethyl)-2,3-dihydro-1H-1lambda*6*-benzo[d]isothiazol-3-yl]-2-methyl-indol-1-yl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C26H24N2O5S
Mol. Mass.:
476.544
SMILES:
Cc1c(C2N(CCOc3ccccc3)S(=O)(=O)c3ccccc23)c2ccccc2n1CC(O)=O
Structure:
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