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Target
Vasopressin V2 receptor
Ligand
BDBM50319813
Substrate
n/a
Meas. Tech.
ChEMBL_634857 (CHEMBL1120489)
Ki
21±n/a nM
Citation
 Crombie, AL; Antrilli, TM; Campbell, BA; Crandall, DL; Failli, AA; He, Y; Kern, JC; Moore, WJ; Nogle, LM; Trybulski, EJ Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists. Bioorg Med Chem Lett 20:3742-5 (2010) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50319813
Synonyms:
(4-(4-(benzo[b]thiophen-3-yl)naphthalen-1-yl)-2-chlorophenyl)((1S,5R)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)methanone | CHEMBL1085624
Type:
Small organic molecule
Emp. Form.:
C35H32ClNOS
Mol. Mass.:
550.153
SMILES:
C[C@@]12C[C@@H](CC(C)(C)C1)N(C2)C(=O)c1ccc(cc1Cl)-c1ccc(-c2csc3ccccc23)c2ccccc12 |r|
Structure:
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